ÐÂÎÅ×ÊѶ
±³¿¿±³£ºÁ½ÆªCellÎÄÕ½Òʾ×ÔÉíÃâÒß¼²²¡Õï¶ÏÑо¿Ð½øÕ¹
- ·ÖÀࣺ»ªÓ¯ÊÓ½Ç
- ×÷ÕߣºÐ¡¸ß
- À´Ô´£ºk8¿·¢(Öйú)¹«ÖÚºÅ
¡¾¸ÅÒªÃèÊö¡¿×ÔÉíÃâÒß¼²²¡ÊÇÑÏÖØΣº¦ÈËÀཡ¿µµÄÃâÒß¹¦ÄÜÎÉÂÒÐÔ¼²²¡£¬¶àÊý×ÔÉíÃâÒß²¡¾ù°éÓÐÌØÕ÷ÐÔµÄ×ÔÉí¿¹Ì壬Òò´Ë£¬×ÔÉí¿¹Ìå¼ì²âÒѳÉΪÕï¶Ï×ÔÉíÃâÒßÐÔ¼²²¡µÄÖØÒªÊֶΡ£
±³¿¿±³£ºÁ½ÆªCellÎÄÕ½Òʾ×ÔÉíÃâÒß¼²²¡Õï¶ÏÑо¿Ð½øÕ¹
¡¾¸ÅÒªÃèÊö¡¿×ÔÉíÃâÒß¼²²¡ÊÇÑÏÖØΣº¦ÈËÀཡ¿µµÄÃâÒß¹¦ÄÜÎÉÂÒÐÔ¼²²¡£¬¶àÊý×ÔÉíÃâÒß²¡¾ù°éÓÐÌØÕ÷ÐÔµÄ×ÔÉí¿¹Ì壬Òò´Ë£¬×ÔÉí¿¹Ìå¼ì²âÒѳÉΪÕï¶Ï×ÔÉíÃâÒßÐÔ¼²²¡µÄÖØÒªÊֶΡ£
- ·ÖÀࣺ»ªÓ¯ÊÓ½Ç
- ×÷ÕߣºÐ¡¸ß
- À´Ô´£ºk8¿·¢(Öйú)¹«ÖÚºÅ
- ·¢²¼Ê±¼ä£º2021-11-23 13:37
- ·ÃÎÊÁ¿£º
×ÔÉíÃâÒß¼²²¡ÊÇÑÏÖØΣº¦ÈËÀཡ¿µµÄÃâÒß¹¦ÄÜÎÉÂÒÐÔ¼²²¡£¬¶àÊý×ÔÉíÃâÒß²¡¾ù°éÓÐÌØÕ÷ÐÔµÄ×ÔÉí¿¹Ì壬Òò´Ë£¬×ÔÉí¿¹Ìå¼ì²âÒѳÉΪÕï¶Ï×ÔÉíÃâÒßÐÔ¼²²¡µÄÖØÒªÊֶΡ£µ«ÊÇ£¬ÓÉÓÚ¼ì²âµÄÁéÃô¶È¼°¼ì²âͨÁ¿µÄÏÞÖÆ£¬ÁÙ´²ÈÔ³öÏÖ©ÕïÇé¿ö£¬ÇÒÄ¿Ç°ºÜ¶àÁÙ´²±íÏÖÏàËƵļ²²¡£¬Èç¶ùͯ¶àϵͳÑ×Ö¢×ÛºÏÖ¢£¨MIS-C£©¡¢Ð¹ڷÎÑ×£¨COVID-19£©¡¢´¨Æ鲡£¨KD£¬Kawasaki disease£©µÄºÜ¶àеÄ×ÔÉí¿¹ÌåÉÐδ·¢ÏÖ¡£
´Ë´Î»ªÓ¯ÊÓ½ÇΪ´ó¼Ò½âÎöÁË2020Äê11ÔÂ12ÈÕ·¢±íÔÚCell£¨IF£º41.582£©ÉϵÄ2ƪ“±³¿¿±³”ÎÄÕ£¬Ñо¿¾ù²ÉÓÃÈËÀ൰°×ÖÊ×éоƬ·¢ÏÖMIS-CµÄ×ÔÉí¿¹ÌåÌØÕ÷£¬Ï£ÍûÄÜΪ´ó¼Ò¿ªÕ¹×ÔÉíÃâÒß¼²²¡µÄ±êÖ¾ÎïÌṩһ¶¨µÄ²Î¿¼¡£
| °¸ÀýÒ»:¶ùͯ¶àϵͳÑ×Ö¢×ÛºÏÕ÷ºÍCOVID-19µÄ×ÔÉí¿¹ÌåÑо¿
MIS-CÊÇÓëCOVID-19¸ÐȾÏà¹ØµÄ²¢·¢Ö¢£¬ÆäÓëCOVID-19»¼ÕßÁÙ´²±íÏÖÏàËÆ£¬µ«ÃâÒßѧÌØÕ÷²îÒìÉв»Çå³þ¡£¸ÃÑо¿ÄÉÈëµÄÈËȺ°üÀ¨£ºMIS-C»¼Õߣ¨N=9£©¼°»Ö¸´ÆÚ»¼Õߣ¨N=2£©¡¢¶ùͯCOVID-19»¼Õߣ¨N=6£©¼°»Ö¸´ÆÚ»¼Õߣ¨2£©¡¢ÇàÄêCOVID-19»¼Õߣ¨N=4£©¼°»Ö¸´ÆÚ»¼Õߣ¨N=2£©¡¢½¡¿µ¶ùͯ£¨N=4£©£¬Ñо¿ÕßÊ×Ïȼì²âÁË92ÖÖѪ½¬Ï¸°ûÒò×Ó±í´ï£¬Í¨¹ý²ã´Î¾ÛÀàºÍPCA·ÖÎö·¢ÏÖMIS-C£¬COVID-19ºÍ½¡¿µÑù±¾¿ÉÒÔ·Ö±ð¾Û¼¯ÔÚÒ»Æð£¬ÆäÖÐÇ÷»¯Òò×Ó£¨CXCL5¡¢CXCL11¡¢CXCL1ºÍCXCL6£©ºÍϸ°ûÒò×Ó£¨IL-17A¡¢CD40ºÍIL-6£©¿ÉÒÔ½«MIS-C»¼ÕßÓë¶ùͯCOVID-19 »¼ÕßÇø·Ö¿ª£¨Í¼1A¡¢B£©¡£½ÓÏÂÀ´£¬Ñо¿ÈËÔ±Èë×éÁË9ÃûMIS-C»¼Õߣ¬5Ãû½¡¿µ¶ùͯºÍ7ÃûÇàÄêCOVID-19»¼Õߣ¬Í¨¹ýÖÊÆ×Á÷ʽ½øÐÐÍâÖÜѪÃâÒß±íÐÍ·ÖÎö£¬ËäÈ»ÕûÌåÉÏ3×éÖ®¼ä¾ßÓÐÏàËƵÄÑÇȺ·Ö²¼£¨Í¼1C£©£¬µ«Ä³Ð©Ìض¨ÃâÒßϸ°ûÀàÐÍ£¨ÈçCD4+Tϸ°û£©µÄ±ÈÀý·¢ÉúÁËÏÔÖø¸Ä±ä£¨Í¼1D£©¡£½á¹û±íÃ÷MIS-C»¼ÕßÓë¶ùͯCOVID-19»¼ÕßÔÚϸ°ûÒò×Ó±í´ïºÍÃâÒßϸ°ûÑÇȺÀàÐͱÈÀý·½Ãæ¾ù´æÔÚÏÔÖøµÄ²î±ð¡£
ͼ1.MIS-CºÍCOVID-19¡¢½¡¿µ¶ÔÕÕµÄϸ°ûÒò×ÓÓëϸ°ûÑÇÐͲîÒì
Ëæºó£¬Ñо¿ÈËÔ±²ÉÓÃÈËÀ൰°×ÖÊ×éоƬ¶ÔMIS-C£¨N=9£©ºÍ½¡¿µ¶ÔÕÕ£¨N=4£©µÄѪ½¬½øÐÐ×ÔÉí¿¹Ìå¼ì²â£¬·¢ÏÖÁË189¸öIgG×ÔÉí¿¹ÌåºÍ108¸öIgA×ÔÉí¿¹Ìå·¢ÉúÁËÏÔÖø±ä»¯¡£ÆäÖÐһЩÒÑÖªµÄµÄ¼²²¡×ÔÉí¿¹Ì壬ÀýÈ翹-La£¨ÏµÍ³ÐÔºì°ßÀÇ´¯ºÍ¸ÉÔï×ÛºÏÕ÷µÄÌØÕ÷ÐÔ×ÔÉí¿¹Ô£©ºÍ¿¹-Jo-1£¨ÌØ·¢ÐÔÑ×Ö¢ÐÔ¼¡²¡µÄÌØÕ÷£©ÔÚMIS-C»¼ÕßÖÐÏÔÖøÉý¸ß£¬±íÃ÷MIS-C¿ÉÄÜÓë¾µäµÄ×ÔÉíÃâÒßÐÔ¼²²¡ÓÐһЩ¹²Í¬µÄ²¡ÀíÉúÀíѧ£¨Í¼2£©¡£×îÖØÒªµÄÊÇÈËÀ൰°×ÖÊ×éоƬ·¢ÏÖÁ˺ܶàûÓб»¼Ç¼¹ýÓë×ÔÉíÃâÒßÐÔ¼²²¡ÓйØÁªµÄ×ÔÉí¿¹Ì壬¶ÔÓ¦¿¹Ô³ÊÏÖÁ˶àÖÖ×éÖ¯ÌØÒìÐԵıí´ï£¬ÀýÈçÄÚƤºÍÐÄÔà×éÖ¯ÖÐÌØÒìÐÔ±í´ïµÄ¿¹ÔP2RX4¡¢ECE1ºÍMMP14£¬ÒÔ¼°Î¸³¦µÀÌØÒì±í´ïµÄ¿¹ÔMUC15¡¢TSPAN13ºÍSH3BP1¡£ÕâЩ½á¹û±íÃ÷ÁËMIS-C»¼ÕßÓë¶ùͯCOVID-19»¼Õß´æÔÚ²»Í¬µÄ×ÔÉí¿¹Ìå·´Ó¦£¬ºóÐøÈçÄÜÔÚ´óÑù±¾ÖÐÑéÖ¤£¬»òÐí¿ÉÒÔ×÷ΪMIS-CÕï¶ÏµÄ±êÖ¾Îï¡£
ͼ2.MIS-CºÍ½¡¿µ¶ÔÕÕµÄ×ÔÉí¿¹Ìå²îÒì
| °¸Àý¶þ:¶ùͯ¶àϵͳÑ×Ö¢×ÛºÏÕ÷ºÍ´¨Æ鲡µÄ×ÔÉí¿¹ÌåÑо¿
³ýÁËCOVID-19,MIS-C»¹Óë´¨Æ鲡ÓÐ×ÅÏàËƵÄÁÙ´²±íÏÖ£¬ÎªÁËÑо¿ÈýÕß¼äµÄÑ×Ö¢ºÍ×ÔÉí¿¹Ìå²îÒ죬¸ÃÑо¿Ê×ÏÈÄÉÈëÁË13ÃûMIS-C¡¢41Ãû¶ùͯCOVID-19»¼Õß¡¢28Ãû´¨Æ鲡¶ùͯºÍ19Ãû½¡¿µ¶ùͯ£¬Ñо¿Õß¼ì²âÁË180ÖÖѪ½¬Ï¸°ûÒò×Ó±í´ï£¬½á¹û·¢ÏÖMIS-C¡¢¶ùͯCOVID-19»¼Õß¡¢´¨Æ鲡¶ùͯµÄϸ°ûÒò×Ó£¨IL-6¡¢IL-17AµÈ£©´æÔÚÏÔÖø²îÒ죬PCA·ÖÎö½ÒʾÈýÕßÖ®¼ä´æÔÚÃ÷ÏÔÇø±ð£¨Í¼3A¡¢B£©¡£ÎªÁ˸üºÃµØÁ˽âÕâÈýÖÖ¼²²¡µÄ²îÒ죬Ñо¿ÈËԱͨ¹ýÁ÷ʽϸ°ûÊõÆÀ¹ÀÁËÍâÖܵ¥ºËϸ°û±íÐÍ£¬ÓëCOVID-19Ïà±È£¬¸ßÑ×Ö¢MIS-C»¼Õߺʹ¨Æ鲡»¼ÕßµÄ×ÜTϸ°û±ÈÀý¾ù½ÏµÍ£¬²¢ÇÒ·¢ÏÖÁËMIS-CºÍ´¨Æ鲡֮¼ä´æÔÚÃ÷ÏÔ²îÒìµÄTϸ°ûÑÇȺ£¨Í¼3C¡¢D£©¡£ÕâЩ½á¹û˵Ã÷ÁËMIS-C»¼Õß¡¢¶ùͯCOVID-19»¼Õß¡¢´¨Æ鲡»¼ÕßÈýÕßÔÚϸ°ûÒò×Ó±í´ïºÍÃâÒßϸ°ûÑÇȺÀàÐͱÈÀý·½Ãæ¾ù´æÔÚÏÔÖøµÄ²î±ð¡£
ͼ3. MIS-CºÍCOVID-19¡¢´¨Æ鲡¡¢½¡¿µ¶ÔÕÕµÄϸ°ûÒò×ÓÓëϸ°ûÑÇÐͲîÒì
Ëæºó£¬Ñо¿ÈËÔ±Èë×éÁË12ÃûMIS-C¡¢28Ãû´¨Æ鲡¶ùͯ¡¢5Ãû¶ùͯCOVID-19»¼ÕßÒÔ¼°11Ãû½¡¿µ£¨Í¼4A£©£¬·¢ÏÖÁË26¸ö¹²Í¬µÄGOÌõÄ¿£¬ÕâЩGO¹ý³ÌÉæ¼°ÁÜ°Íϸ°û»î»¯¹ý³Ì¡¢Á×ËữÐźÅͨ·ºÍÐÄÔà·¢Óý£¨Í¼4B£©¡£ÒòΪÐļ¡Ñ׺ÍÐŦÄÜÊÜËðÊÇ MIS-C ÁÙ´²±íÏֵıêÖ¾£¬GSEA½á¹ûÒ²±íÃ÷ÁËÐÄÔà·¢Óý¹ý³ÌÓëMIS-CµÄ×ÔÉí¿¹ÌåÐźųÊÏÖÕýÏà¹Ø£¨Í¼4C£©£¬ÓÚÊÇÑо¿Õß¼ì²âÁ˸»¼¯µ½´ËÉúÎïѧ¹ý³ÌÖеÄÒ»¸ö·Ç³£ÖØÒªµÄ×ÔÉí¿¹ÌåÄÚƤÌǵ°°×EndoglinµÄ×ÔÉí¿¹Ì壬ELISA½á¹ûÑéÖ¤ÁËMIS-C»¼ÕßµÄanti-Endoglinˮƽ¸ßÓÚ½¡¿µ¶ÔÕÕ£¨Í¼4D£©£¬²¢ÇÒMIS-C»¼ÕßѪ½¬ÖÐEndoglinµ°°×ˮƽҲÏÔÖø¸ßÓÚ½¡¿µÕߺÍCOVID-19»¼Õߣ¨Í¼4E£©£¬EndoglinÓëÄÚƤËðÉËÏà¹Ø£¬Òò´Ëanti-Endoglin»òÐí¿ÉÒÔ×÷Ϊ¼à²âÕâЩ»¼ÕßÄÚƤËðÉ˵ÄÉúÎï±êÖ¾Îï¡£´ËÍ⣬ÔÚÆäËû¸»¼¯µÄGOÌõÄ¿Öдó¶àÊýÉæ¼°ÐźÅתµ¼£¬ÌرðÊÇͨ¹ýÀÒ°±ËáºÍË¿°±Ëá²Ð»ùµÄÁ×Ëữתµ¼Ðźţ¨Í¼4B£©£¬ÓÚÊÇÑо¿ÕßҲͨ¹ýELISA¼ì²âÁ˼¸¸öÏà¹Øµ°°×µÄ±í´ï£¬½á¹û·¢ÏÖÁËCSNK¼Ò×åµ°°×ºÍMAP2K2ÔÚMIS-C»¼ÕßÖÐÏÔÖøÉý¸ß£¨Í¼4F£©¡£ÕâЩ½á¹û±íÃ÷MIS-C»¼ÕßÓë¶ùͯCOVID-19»¼Õß¡¢´¨Æ鲡¶ùͯÔÚ´æÔÚ²»Í¬µÄ×ÔÉí¿¹Ìå·´Ó¦£¬ÕâЩ×ÔÉí¿¹ÌåÓëÄÚƤËðÉ˼°Á×ËữÐźÅͨ·¼¤»îÃÜÇÐÏà¹Ø£¬»òÐí¿ÉÒÔ×÷ΪÕï¶Ï MIS-CµÄ×ÔÉí¿¹Ìå±êÖ¾Îï¡£ ¶ùͯ£¬²ÉÓÃÈËÀ൰°×ÖÊ×éоƬ¶ÔÊÕ¼¯µÄѪ½¬Ñù±¾½øÐÐ×ÔÉí¿¹Ìå¼ì²â£¬·¢ÏÖÁ˺ܶàMIS-CÓëÆäËûÈý×é²îÒìµÄ×ÔÉí¿¹Ì壬֮ºóÑо¿Õß°´ÕÕ²îÒ챶Êý½øÐÐÁËÅÅÐò£¬Í¨¹ýGSEA·ÖÎöÁ˼ø¶¨µ½µÄ¿¹Ô¸»¼¯µÄGOÌõÄ¿£¬×îºó½øÐн»¼¯·ÖÎö
ͼ4.MIS-CºÍCOVID-19¡¢´¨Æ鲡¡¢½¡¿µ¶ÔÕÕµÄ×ÔÉí¿¹Ìå²îÒì
ÎÒÃÇ¿ÉÒÔ¿´µ½£¬Á½ÆªÎÄÕ¾ù·ÖÎöÁËMIS-CºÍCOVID-19»¼ÕßµÄÃâÒßѧ·½ÃæµÄ²îÒ죬¶ø×ÔÉí¿¹Ìå¼ì²âÔÚÁ½ÆªÎÄÕÂÀïÃæѹÖá³ö³¡£¬Æ𵽵㾦֮±ÊµÄ×÷Ó᣻úÌåÕë¶Ô×ÔÉí¿¹Ô²úÉú´óÁ¿×ÔÉí¿¹ÌåºóÒýÆðµÄÂýÐÔ¼²²¡£¬¼ì²â»¼ÕßÌåÄÚÌØÒìÐÔµÄ×ÔÉí¿¹ÌåÓÃÒÔÕï¶ÏºÍ·¢²¡»úÀíÑо¿ÓÐמ޴óµÄ¼ÛÖµ¡£½üÄêÀ´£¬Ëæ×Å¿¹Ìåɸѡ¼¼ÊõµÄÓ¦Óã¬Ô½À´Ô½¶àµÄ×ÔÉí¿¹Ìå±»·¢ÏÖ£¬Ó¦Ó÷¶Î§³ý×ÔÉíÃâÒßÐÔ¼²²¡Í⣬ÒÑÍØÕ¹ÖÁÏû»¯¡¢ÉúÖ³¼°Ö×ÁöµÈÁìÓò¡£k8¿·¢(Öйú)ÌṩµÄHuProtTM 20K×÷Ϊһ¿î¸ßͨÁ¿µÄÈËÀ൰°×ÖÊоƬ£¬ÊÇ×ÔÉí¿¹ÌåɸѡµÄÀûÆ÷£¬½«¼«´óµÄ¼ÓËÙÄúµÄ¿ÆÑнø³Ì¡£
ÉÏÊöÁ½ÏîÑо¿ÓÐ×ÅÏàͬµÄ˼·£¨k8¿·¢(Öйú)ÌṩHuProt 20KÈËÀ൰°×ÖÊ×éоƬ¼ì²â·þÎñ£©£º
| Ïà¹ØÎÄÏ×
1.Gruber C N , Patel R S , Trachtman R , et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)[J]. Cell, 2020, 183(4):982-995.e14.
2.Consiglio C R , Cotugno N , Sardh F , et al. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19[J]. Cell, 2020, 183(4):968-981.e14.
µØÖ·£ºÉϺ£ÊÐãÉÐÐÇøÂÌÖÞ»·Â·396Ū5´±4²ã
µç»°£º400-869-2936£¬021-33968791
ÓÊÏ䣺support@wayenbiotech.com
´«Õ棺021-33938792
QQ£º2120485725
Õ½ÂÔºÏ×÷
Õ½ÂÔºÏ×÷
| Full Moon | RayBiotech | CDI | IZON | Bio-Rad | R&D Systems | IsoPlexis | ÄÏÄ£ÉúÎï | Å·Ò×ÉúÎï | ÆäÃ÷ÐÅÏ¢ | ÃÀ¼ªÉúÎï | ÂóÌØ»æÆ× |
Ìرð˵Ã÷£º±¾ÍøËùÓÐÍøÒ³¾ùΪk8¿·¢(Öйú)Ô´´ÐÅÏ¢£¬×ªÔرØÐëÕ÷Çók8¿·¢(Öйú)ͬÒ⣬²¢Í¬Ê±×¢Ã÷±¾ÍøÃû³Æ¼°ÍøÖ·¡£