ÍâÃÚÌåÑо¿
ÍâÃÚÌ嶨Á¿µ°°×ÖÊ×éѧ·þÎñ
ÍâÃÚÌ壨Exosomes£©ÊÇ´óСΪ30-150nm£¬¾ßÓÐÁ×֬˫·Ö×Ó²ãĤ½á¹¹µÄ΢СÄÒÅÝ¡£ÍâÃÚÌå¿ÉЯ´ø·á¸»µÄRNAs¡¢Ö¬ÖÊ¡¢µ°°×ÖʵÈÉúÎï»îÐÔ·Ö×Ó£¬²ÎÓëϸ°û¼äµÄͨѶÓëµ÷¿Ø¡£´ÓÍâÃÚÌåÑо¿×¨ÒµÊý¾Ý¿â——ExoCartaºÍVesiclepediaÖмǼµÄÊý¾Ý¿ÉÒÔ¿´³ö£¬ÍâÃÚÌåЯ´øµÄµ°°×Öʵķḻ³Ì¶ÈÓÈΪͻ³ö¡£ÍâÃÚÌ嵰Я´øµÄµ°°×ÖÊÊÇÍâÃÚÌå±êÖ¾Îï¡¢ÍâÃÚÌåÔØÒ©¡¢ÍâÃÚÌå·Ö×Ó»úÖÆÑо¿µÄÖ÷Òª·Ö×Ó×¥ÊÖ¡£
ÍâÃÚÌåµ°°×ÖÊÒ²ÊǵǼCNSÕý¿¯×î¶àµÄÑо¿¶ÔÏó¡£³ý´ËÖ®Í⣬ÍâÃÚÌåµ°°×ÓÈÆäÊÇĤµ°°×¾ßÓзdz£ÖØÒªµÄÁÙ´²×ª»¯¼ÛÖµ£¬Ò²ÊÇÁÙ´²×ª»¯Ñо¿ÖеÄг衣×éÖ¯ÍâÃÚÌåÓëѪ½¬ÍâÃÚÌå±È¶Ô·ÖÎöÒ²³ÉΪ·¢ÏÖÐÂÐͼ²²¡±êÖ¾ÎïµÄ¾µäʵÑé·½°¸¡£
ÔÚÍâÃÚÌåµ°°×±êÖ¾ÎïÏà¹ØÑо¿ÖУ¬Ñª½¬/ѪÇåÑù±¾ÊÇÖ÷ÒªÑо¿ÔØÌ塣Ȼ¶ø£¬Ñª½¬/ѪÇåÖк¬ÓдóÁ¿µÄÔØÖ¬µ°°×£¬Èç¸ßÃܶÈÖ¬µ°°×ÖÊHDL£¬µÍÃܶÈÖ¬µ°°×ÖÊLDL£¬¼«µÍÃܶÈÖ¬µ°°×VLDL£¬ÈéÃÓ΢Á£CMµÈ¡£ÍâÃÚÌåÓëÕâЩ֬µ°°×ÖÊÔÚÎﻯÐÔÖÊÉϾßÓнϴóµÄÏàËÆÐÔ¡£³£¹æµÄÍâÃÚÌå·ÖÀë·½·¨£¬È糬ËÙÀëÐĺͳÁµí·¨µÈ¶¼ÎÞ·¨ÓÐЧȥ³ýѪ½¬/ѪÇåÖеÄÖ¬µ°°×£¬ÑÏÖظÉÈÅÁËÏÂÓÎÖÊÆ×ʵÑéÊý¾ÝµÄ¼ì³öÂʺͿɿ¿ÐÔ¡£Í¬Ê±£¬ÊµÑéÑù±¾À´Ö®²»Ò×£¬ÈçºÎ¾¡¿ÉÄÜÀûÓøüÉÙµÄÑù±¾»ñµÃ¸ü¿É¿¿µÄʵÑéÊý¾Ý£¬³ÉΪÍâÃÚÌåµ°°×ÖÊ×éѧÑо¿¿ÆÑÐȺÌ干ͬÃæ¶ÔµÄ¼¼ÊõÎÊÌâ¡£
| ÍâÃÚÌåµ°°×ÖÊ×é·þÎñ
k8¿·¢(Öйú)¿ª·¢ÁËÒ»Ì×ÍêÕûµÄÍâÃÚÌåµ°°×ÖÊ×éѧÑо¿¼¼Êõ·þÎñÌåϵ£¬Õë¶Ô²»Í¬ÀàÐ͵ÄÑù±¾·Ö±ð²ÉÓÃרÊôµÄÍâÃÚÌåÌáÈ¡·½·¨£¬È糬ËÙÀëÐÄ¡¢³ß´çÅÅ×è¡¢ÃܶÈÌݶÈÀëÐĵȡ£Í¬Ê±£¬¶Ôµ°°×ÖÊ×éѧʵÑéÇ°´¦Àí½øÐÐÁËϵͳÐÔ´´ÐÂÓÅ»¯£¬½«Ñù±¾ÓÃÁ¿½µµÍµÄͬʱ»ñÈ¡¸ßÖÊÁ¿Êý¾Ý£¬ÈçÀûÓÃ0.5mLѪ½¬¼´¿ÉÍê³ÉÍâÃÚÌåµÄ·ÖÀëÓëµ°°×ÖÊ×éɸѡ¹¤×÷¡£
ÔÚÑù±¾Ê¹ÓÃÁ¿ºÍ¼ì³öµ°°×ÊýÉÏ£¬k8¿·¢(Öйú)µÄ¼¼Êõƽ̨²»¶Ï³å»÷ÍâÃÚÌåµ°°×ÖÊ×éѧµÄ¼ì²âµÄÉÏÏÞ¡£ÀýÈ磺ÔÚÈËÍâÃÚÌåѪ½¬µ°°××é¼ø¶¨ÀúÊ·¼Ç¼ÒÑ´ïµ½2336ÖÖµ°°×ÖÊ£¬²¢ÇÒÕâ¸öÊý¾Ý¼Ç¼ÿÌ춼¿ÉÄܱ»ÔÙ´ÎÍ»ÆÆ¡£½ØֹĿǰ£¬k8¿·¢(Öйú)ÒѾÍê³É³¬¹ý30ÖÖÑùÆ·ÀàÐ͵ÄÑùÆ·ÍâÃÚÌåÖƱ¸Óë·ÖÎö¡£¶ÔÓÚÌØÊâÑù±¾È磺θҺ¡¢ÄÔ»ýÒº¡¢ÄÔ¼¹Òº¡¢µ¨Ö¡¢Î¢ÉúÎïÅàÑøÒº¡¢Ö²ÎïÅàÑøÒºµÈ£¬Ò²ÀÛ»ýÁ˷ḻµÄÏîÄ¿¾Ñ飬¿É³Ð½Ó¸´ÔÓÑùÆ·ºÍÏîÄ¿µÄÑо¿·þÎñÐèÇó¡£
¶ÔÓÚÍâÃÚÌåµ°°×ÖÊ×éѧÑо¿À´Ëµ£¬ÍâÃÚÌåµÄ´¿¶ÈÖÁ¹ØÖØÒª¡£ÔÚ×éÖ¯ÍâÃÚÌåµÈÈȵãÑо¿ÁìÓò£¬k8¿·¢(Öйú)¾¹ýϵͳµÄÑз¢ºÍ±È¶Ô·ÖÎö£¬¿ª·¢³öµÄ×éÖ¯ÍâÃÚÌå·ÖÀë´¿»¯·½·¨¿ÉÏÔÖøÌá¸ßÍâÃÚÌåµÄ´¿¶È£¬´ïµ½TopÔÓÖ¾µÄÒªÇó¡£
k8¿·¢(Öйú)ÓµÓÐÖÊÆ×¼¼ÊõºÍ¿¹ÌåоƬÁ½´óƽ̨£¬Õë¶Ô²»Í¬µÄÑо¿ÐèÇó£¬Ñ¡Ôñ¸üÓŵļ¼Êõ¡£ÖÊÆ×¼¼Êõ¶ÔÓÚ¼ø¶¨Äܹ»ÔÚÍâÃÚÌåÖÐЯ´øµÄе°°×£¨ÓÈÆäÊÇĤµ°°×£©¾ßÓÐÏÔÖøÓÅÊÆ£¬¶ø¿¹ÌåоƬÔòÀûÓÿ¹Ô¿¹Ìå·´Ó¦µÄÌØÒìÐÔÔÀí£¬¶ÔÓÚÍâÃÚÌåÖÐЯ´øµÄ·ÖÃÚÐ͵ĵ°°×µÄ¼ø¶¨¸ü¼ÓÁéÃôºÍ׼ȷ£¨¿¹ÌåоƬĿǰ¿É¼ì²â³¬¹ý500ÖÖ·ÖÃÚµ°°×£©¡£
| ¾µä°¸Àý£ºÑª½¬ÍâÃÚÌåS100-A9µ°°×¼¤»îNF-κB´Ù½øÁÜ°ÍÁö¸´·¢
Ѫ½¬ÖеÄÍâÃÚÌåµ°°×¼È¿ÉÒÔµ±×÷±êÖ¾ÎҲ¿ÉÒÔ½øÐлúÀíÑо¿£¿
Ê×ÏÈ£¬Ñо¿ÈËÔ±½«ÂýÐÔÁÜ°ÍÁö£¨CLL£©»¼Õß·ÖΪ2¸öÑÇ×飺¼²²¡½øÕ¹Æںͼ²²¡ÂýÐÔÆÚ¡£È»ºóÀûÓÃÖÊÆ×¼¼Êõ·ÖÎöÁË»¼ÕßѪ½¬ÍâÃÚÌåµ°°×ÖÊ×飬·¢ÏÖS100-A9µ°°×ÔÚ½øÕ¹ÆÚCLL»¼ÕßÖÐÃ÷ÏԸ߱í´ï£¬¿ÉÒÔ×÷ΪCLL½øÕ¹ÆÚÕï¶ÏµÄ¸¨Öú±êÖ¾Îï¡£½øÒ»²½£¬Ñо¿ÈËԱͨ¹ýÉúÐÅ·ÖÎö·¢ÏÖ½øÕ¹ÆÚCLL»¼ÕßÍâÃÚÌåÖеĸ߱í´ïµ°°×ÖÊÖ÷ÒªÓëÑ×Ö¢ºÍÑõ»¯Ó¦¼¤Óйأ¬¶øNF-κBͨ·ÕýÊdzнӴËЧӦµÄ¹Ø¼üͨ·¡£Í¨¹ý´Ó½øÕ¹ÆÚCLL»¼ÕßÖзÖÀ븻º¬S100-A9µ°°×µÄÍâÃÚÌå¼ÓÈëCLL»¼ÕßµÄPBMCϸ°ûÖУ¬Ö¤ÊµÁËS100-A9+ÍâÃÚÌåÄܹ»Ã÷ÏÔ´Ù½ø½øÕ¹ÆÚCLL»¼ÕßPBMCϸ°ûÖÐIκBαµ°°×µÄÁ×ËữÉϵ÷£¬½øÒ»²½¼¤»îNF-κBͨ·¡£
¸ÃÑо¿Ö¤Í¨¹ýѪ½¬ÍâÃÚÌåµ°°××é·ÖÎö²»½öÕÒµ½¸¨ÖúÕï¶Ï½øÕ¹ÆÚCLLµÄ±êÖ¾Î²¢Ö¤ÊµÁËS100-A9+ÍâÃÚÌå¿Éͨ¹ýÐγÉÕýÏò·´À¡µ÷¿Ø£¬²»¶Ï¼¤»î½øÕ¹ÆÚCLL»¼Õß×ÔÉíPBMCϸ°ûÖеÄNF-κBͨ·£¬´Ù½øCLL½øÕ¹µÄÌØÊâ»úÀí¡£
| ¿Í»§ÎÄÏ×
[1]. Zhang Luwen, Zhao Qiong, Cang Hui et al. Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities. Adv Sci (Weinh), 2022, undefined: e2105811.£¨Õã½´óѧҽѧԺ¸½Êô¶ùͯҽԺ ϸ°ûÉÏÇ壩IF=15.1
[2]. Han Qiao, Jingtian Mei, Kai Yuan, et al. Immune-regulating strategy against rheumatoid arthritis by inducing tolerogenic dendritic cells with modified zinc peroxide nanoparticles. J Nanobiotechnology. 2022 Jul 14;20(1):323.£¨ÉϺ£µÚ¾ÅÈËÃñÒ½Ôº ϸ°ûÉÏÇ壩IF=9.429
[3]. Qiao Yang, Mingjing Chen, Jiaoyang Gu, et al. Novel Biomarkers of Dynamic Blood PD-L1 Expression for Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer Patients. Front Immunol. 2021 Apr 16;12:665133.£¨Â½¾ü¾üÒ½´óѧÐÂÇÅÒ½Ôº Ѫ½¬£©IF=7.561
[4]. Tian Wang, Zhe Jian, Andrius Baskys, et al. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020 Oct;257:120264.£¨Î÷°²ÊÐÖÐÐÄÒ½Ôº ϸ°ûÉÏÇ壩IF=12.479
[5]. Ruixiang Li, Yuwei He, Ying Zhu, et al. Expressway to Rheumatoid Arthritis by Macrophage-derived Microvesicle-Coated Nanoparticles. Nano Lett. 2019 Jan 9;19(1):124-134.£¨¸´µ©´óѧÖÇÄÜ»¯µÝÒ©½ÌÓý²¿ÖصãʵÑéÊÒ ½ºÌõ£©IF=10.8
[6]. Zhenzhen Chen, Liangshun You, Lei Wang, et al. Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo. J Exp Clin Cancer Res. 2018 Aug 13;37(1):190.£¨Õã½´óѧҽѧԺµÚÒ»¸½ÊôÒ½Ôº ϸ°ûÁѽâÒº£©IF=11.161
µØÖ·£ºÉϺ£ÊÐãÉÐÐÇøÂÌÖÞ»·Â·396Ū5´±4²ã
µç»°£º400-869-2936£¬021-33968791
ÓÊÏ䣺support@wayenbiotech.com
´«Õ棺021-33938792
QQ£º2120485725
Õ½ÂÔºÏ×÷
Õ½ÂÔºÏ×÷
| Full Moon | RayBiotech | CDI | IZON | Bio-Rad | R&D Systems | IsoPlexis | ÄÏÄ£ÉúÎï | Å·Ò×ÉúÎï | ÆäÃ÷ÐÅÏ¢ | ÃÀ¼ªÉúÎï | ÂóÌØ»æÆ× |
Ìرð˵Ã÷£º±¾ÍøËùÓÐÍøÒ³¾ùΪk8¿·¢(Öйú)Ô´´ÐÅÏ¢£¬×ªÔرØÐëÕ÷Çók8¿·¢(Öйú)ͬÒ⣬²¢Í¬Ê±×¢Ã÷±¾ÍøÃû³Æ¼°ÍøÖ·¡£