HuProt™20KÈËÀ൰°××éоƬ£¬Ð¾Æ¬ÉÏÓг¬¹ý2ÍòÖÖÈËÀàÈ«³¤µ°°×ÖÊ£¬¸²¸Ç81%µÄÈËÀà»ùÒò×éORFÇø£¬ÊÇÄ¿Ç°ÊÀ½çÉÏͨÁ¿×î¸ßµÄµ°°×ÖÊоƬ¡£ÖØ×éµ°°×²ÉÓýÍĸ±í´ïϵͳ£¬Öð¸ö½øÐбí´ïÓë´¿»¯¼ø¶¨¡£ÔÚоƬÉÏÿ¸öµ°°×ÖʾùÉèÖü¼ÊõÖظ´£¬²¢ÉèÓжàÖÖÖʿص㣬ȷ±£ÊµÑéÌåϵÎȶ¨¿É¿¿¡£¸ÃоƬÒѾÔÚÑо¿ÁìÓòµÃµ½¹ã·ºµÄÓ¦Óã¬Èçµ°°×ÖÊÏ໥×÷Óá¢×ÔÉí¿¹Ìå±êÖ¾ÎïÆס¢¿¹ÌåÌØÒìÐÔ¡¢Ð¡·Ö×ӰбêÑо¿¡¢DNA/RNAÓëµ°°×»¥×÷Ñо¿¡£
| оƬµ°°×·ÖÀà
HuProt™20KÈËÀ൰°××éоƬͨ¹ý»¯Ñ§ÐÞÊι²¼Û½áºÏ³¬¹ý16794ÖÖÈËÀà»ùÒò±àÂëµ°°×ºÍ124ÖÖСÊó»ùÒò±àÂëµ°°×ÖÊ¡£ÕâЩµ°°×¹ã·º¸²¸ÇÊÜÌ塢ת¼Òò×Ó¡¢¼¤Ã¸¡¢°ûÍâ»ùÖʵ°°×¡¢Ï¸°û¹Ç¼Üµ°°×µÈ30ÓàÖÖµ°°×ÀàÐÍ£¬¿ÉÓÃÓÚ¶àÖÖÉúÎïѧ¹¦ÄܵĴ´ÐÂÑо¿¡£
| оƬµ°°×¹æ¸ñ
¡ñ оƬ±ê×¼£º1×25×76mm¹èƬƬ»ù£¬µ°°×µã¾¶~60μm£¬Ìå»ý0.5~1 nL£»
¡ñ ¼¼ÊõÖظ´£ºÃ¿¸öµ°°×µã2´Î¼¼ÊõÖظ´£»
¡ñ Ó«¹â¼ì²â£º¿ÉʹÓõ¥Ò»»ò¶àÉ«±êÇ©£»
¡ñ ´¿»¯Ìåϵ£ºËùÓе°°×ÖÊÔڷDZäÐÔÌõ¼þÏ£¬Í¨¹ýÕæºË½Íĸ±í´ïÌåϵ±í´ï´¿»¯£»
¡ñ Éú²úÌõ¼þ£ºÎ¶È4-8¡æ£¬Êª¶È30~40%µãÑù£¬4¡æ¹ýÒ¹¹Ì¶¨£¬-80¡æ³¤ÆÚ±£´æ¡£
| оƬÓÅÊÆ
¡ñ ÌåÍâʵÑ飬µ°°×ÔØÁ¿¸ß£¬¼ø¶¨¸üÈ«Ã棻
¡ñ ÎÞÐè¿Ë¡¹¹½¨¡¢Ï¸°ûÅàÑøºÍתȾʵÑ飻
¡ñ ¿ÉÈ·¶¨Ö±½Ó½áºÏµ°°×£¬ÎÞÐèÖÊÆ×¼ø¶¨£»
¡ñ ÊÊÓÃÓÚµ°°×¡¢Ð¡·Ö×Ó¡¢ÑªÇåµÈ¶àÀàÐÍÑù±¾£»
¡ñ Ñé֤ЧÂʸߣ¬ÊµÑé½á¹û׼ȷ¡¢È«Ã棻
¡ñ ¿É¶¨ÖÆСоƬ£¬ÓÃÓÚÀ©´óÑù±¾Ñé֤ʵÑ飻
| HuProt™20KÈËÀ൰°××éоƬ ¼ì²âÁбí
µã»÷´Ë´¦£¬ÏÂÔØÏêϸÁбí
| µ°°×оƬӦÓÃ
HuProt™20KÈËÀ൰°××éоƬÊÊÓÃÓÚÒÔµ°°×ÖÊÏ໥×÷ÓÃΪ»ù´¡ÔÀíµÄ¸÷ÖÖÑо¿ÁìÓò£¬¾ß±¸¹ã·ºµÄÓ¦ÓüÛÖµ¡£ÔÚµ°°×Óëµ°°×Ï໥×÷ÓÃɸѡ¡¢µ°°×ÓëºËËáÏ໥×÷Óüø¶¨·½ÃæÏà±È´«Í³µÄco-IPÁªºÏÖÊÆ×¼ø¶¨µÄ¼¼Êõ·Ïߣ¬¸ü¼Ó¸ßЧºÍ׼ȷ¡£ÔÚС·Ö×ÓÒ©°Ð¼ø¶¨¡¢µ¥¿Ë¡¿¹ÌåÌØÒìÐÔɸѡ¡¢Ö¬Àà½áºÏµ°°×ɸѡ¡¢Ã¸×÷Óõ×Îï¼ø¶¨¼°×ÔÉí¿¹ÌåÀàbiomarkerµÄɸѡµÈÓ¦ÓÃÖУ¬Æä¼¼ÊõÓÅÊƲ»¿ÉÌæ´ú¡£
¡ñ µ°°×ÖÊ-µ°°×ÖÊÏ໥×÷Óà —— Ö×ÁöÇÖÏ®¡¢Î¢ÉúÎï¸ÐȾ¡¢ÃâÒß¡¢ÄÍÒ©¡¢ÐźÅÍøÂç
¡ñ С·Ö×Ó-µ°°×ÖÊÏ໥×÷Óà —— Ò©Îï°Ðµãɸѡ¡¢Ðźŵ÷½Ú¡¢Ï¸°û¹¦Äܵ÷¿Ø
¡ñ ºËËá-µ°°×ÖÊÏ໥×÷Óà —— »ùÒòÐÞ¸´¡¢×ªÂ¼µ÷¿Ø¡¢RNA¶¾ÐÔ¡¢LncRNAµ÷¿Ø»úÖÆ
¡ñ Ö¬Àà-µ°°×ÖÊÏ໥×÷Óà —— ΢ÉúÎï¸ÐȾ¡¢Ö×ÁöÇÖÏ®¡¢ÄÍÒ©¡¢Ö¬´úлµ÷¿Ø
¡ñ ×ÔÉí¿¹ÌåÆ×ɸѡ —— ¼²²¡±êÖ¾Îï(Biomarker)¿ª·¢¡¢¼²²¡»úÖÆÑо¿
¡ñ ø×÷Óõ×Îïɸѡ —— ·ÒëºóÐÞÊε÷¿Ø¡¢ÐźÅÍøÂç¡¢µ°°×¹¦ÄÜ
¡ñ ¿¹ÌåÌØÒìÐÔ¼ì²â —— ¿¹ÌåÌØÒìÐÔÆÀ¼Û¡¢¿¹Ô¼ø¶¨¡¢ÒßÃ翪·¢
£¨Ò»£©¼²²¡±êÖ¾ÎïÑо¿£º×ÔÉí¿¹ÌåÆ×ɸѡ
Ö×Áö¡¢Ñ×Ö¢¡¢×ÔÉíÃâÒßÐÔ¼²²¡£¨È磺ºì°ßÀÇ´¯¡¢Àà·ç¹Ø¡¢¿Ë¡Êϲ¡¡¢¶à·¢ÐÔÓ²»¯£©µÈ¶àÖÖ¼²²¡ÖУ¬ÌåÄÚ²úÉúºÍÀÛ»ý´óÁ¿µÄ×ÔÉí¿¹Ìå¡£HuProt™20Kµ°°××éоƬ¸²¸Ç~2ÍòÖÖÈËÀ൰°×ÖÊ£¬Äܹ»½áºÏ²¢´ó¹æģɸѡÕâЩÈËÀà×ÔÉí¿¹Ì壬´Ó¶øΪ¶àÖÖ¼²²¡µÄÕï¶Ï¡¢Ô¤ºó¡¢Ò©Ð§ÆÀ¼ÛµÈÌṩ·á¸»ºòÑ¡±êÖ¾Îï¡£
HuProt™ 20KÓÃÓÚbiomarkerɸѡµÄ¼¼ÊõÓÅÊÆ
¡ñ оƬ¸²¸Ç½ü2ÍòÖÖÈËÀ൰°×ÖÊ£¬»ñµÃbiomarker¿ÉÄÜÐÔ´ó£»
¡ñ ½ÏÖÊÆ×¼¼Êõ¸üÊÊÓÃÓÚѪÇå/Ѫ½¬µ°°×ɸѡ£»
¡ñ ÌرðÊʺÏ×ÔÉíÃâÒß²¡¼°×ÔÉí¿¹ÌåÀ༲²¡±êÖ¾ÎïµÄɸѡ£»
¡ñ ¿É×·ËÝ×éÖ¯ÖÐ×ÔÉí¿¹Ìå¶ÔÓ¦¿¹ÔµÄÒì³££¬Àí½â·¢²¡»úÀí£»
¡ñ ¿É¶©ÖÆСоƬ£¬ÓÃÓÚÀ©´óÑù±¾Ñé֤ʵÑ飻
¡ñ Ñо¿³É¹ûµÄת»¯Ó¦ÓúͿª·¢Óм«Ç¿±ãÀûÐÔ¡£
µ°°×оƬӦÓð¸Àý£º±³¿¿±³£ºÁ½ÆªCellÎÄÕ½Òʾ×ÔÉíÃâÒß¼²²¡Õï¶ÏÑо¿Ð½øÕ¹
µã»÷´Ë´¦²é¿´ÎÄÏ×½â¶Á
£¨¶þ£©µ°°×ÖÊÏ໥×÷ÓÃÆ×ɸѡ
µ°°×ÖÊÔÚÌåÄÚ»ù±¾È«²¿ÒÔµ°°×¸´ºÏ״̬·¢»Ó¹¦ÄÜ£¬¶Ôµ°°×¸´ºÏÎï³ÉÔ±µÄʶ±ðºÍÑо¿ÊÇÈÏʶºÍÀí½âµ°°×¹¦ÄܵĹؼü¡£¸ßͨÁ¿HuProt 20Kµ°°××éоƬÊǵ°°×£¨¿¹Ì壩»¥×÷Æ×¼ø¶¨µÄÓÐÁ¦¹¤¾ß£¬Í¨¹ýµö¶üµ°°×ÓëоƬÉÏ°ü±»µÄ~2ÍòÖÖ±³¾°ÐÅÏ¢ÇåÎúµÄµ°°×ÖʽøÐл¥×÷·´Ó¦£¬Äܹ»¼«´óÌá¸ßÏ໥×÷Óõ°°×µÄɸѡ·¶Î§ºÍ¹¤×÷ЧÂÊ¡£
HuProt™20Kµ°°××éоƬÓëÃâÒß¹²³Áµí£¨Co-IP£©±È½ÏµÄÓÅÊÆ
¡ñ ÎÞÐè½øÐпË¡¹¹½¨¡¢Ï¸°ûÅàÑøºÍתȾµÈʵÑ飻
¡ñ ÎÞÐèÃâÒß³ÁµíʵÑ飬²»Êܰе°°×±í´ïÁ¿ºÍ¹²³ÁµíЧÂÊÓ°Ï죻
¡ñ Ö±½ÓÅж¨»¥×÷µ°°×£¬ÎÞÐè½øÐÐÖÊÆ×£¨MS£©¼ø¶¨£»
¡ñ ¸ü¼ÓÖ±¹Û¡¢¿É¿¿ºÍ¿ìËÙ£¬ÓÐЧÌá¸ß¹¤×÷ЧÂÊ£»
¡ñ ´ý²âµ°°×ÎÞÌØÒìÐÔ¿¹ÌåÈÔÈ»¿ÉÒÔ½øÐмì²â£»
¡ñ ´ý²âµ°°×ÓÐÎÞ´¿»¯±êÇ©£¨Tag£©¶¼¿ÉÒÔ¼ì²â£»
¡ñ ÌåÍâʵÑ飬¸²¸Ç·¶Î§¸ü¹ã·º£¬¿É¼ø¶¨¸ü¶à»¥×÷µ°°×ÀàÐͺͰе㡣
µ°°×оƬӦÓð¸Àý£ºÓëÒҸβ¡¶¾X»ùÒò£¨HBx-E2£©±äÒìµ°°×»¥×÷µÄËÞÖ÷µ°°×µÄ·¢ÏÖ£¨J Hepatol. 2019 May;70(5):904-917.£©
µã»÷´Ë´¦²é¿´ÎÄÏ×½â¶Á
£¨Èý£©DNA/RNA½áºÏµ°°×ɸѡ
HuProt™20K µ°°××éоƬ¿ÉʵÏÖµ°°×ÖÊÓëºËËᣨDNA/RNA£©ÌØÒìÐÔ½áºÏµÄ¸ßͨÁ¿É¸Ñ¡¡£¸ÃоƬ¿ÉѸËÙ¶¨Î»ÓëÄ¿µÄºËËá½áºÏµÄµ°°×Öʼ°Æä±³ºó·á¸»µÄÉúÎïÐÅÏ¢£¬ÔÚת¼Òò×Óɸѡ¡¢LncRNAµ÷¿Ø¡¢ RNA¶¾ÐÔ¡¢²¡Ô΢ÉúÎïÇÖÏ®µÈÑо¿Öз¢»ÓÖØÒª×÷Óá£
HuProt™ 20K ɸѡºËËá½áºÏµ°°×µÄ¼¼ÊõÓÅÊÆ
¡ñ ÎÞÐè¿Ë¡¹¹½¨¡¢Ï¸°ûÅàÑøºÍתȾʵÑ飻
¡ñ ÎÞÐèϸ°ûºËµ°°×µÄÌáÈ¡£¬²»Êܵ°°×±í´ïˮƽӰÏ죻
¡ñ ÎÞÐè½øÐÐÃâÒß³ÁµíʵÑ飬²»Êܹ²³ÁµíЧÂÊÓ°Ï죻
¡ñ ÓëEMSA¡¢ChIP¡¢RIP±È½Ï£¬¸üÊʺÏɸѡÐèÇó£»
¡ñ Ö±½ÓÈ·¶¨½áºÏµ°°×£¬ÎÞÐè½øÐÐÖÊÆ×¼ø¶¨£»
¡ñ ¿ìËÙ¿É¿¿£¬¸÷µ°°×ÐÅÏ¢ÇåÎú£¬Ñé֤ʵÑé¼ò±ã£»
¡ñ ÌåÍâʵÑ飬¸²¸Ç·¶Î§¸ü¹ã·º£¬¿É¼ø¶¨¸ü¶à»¥×÷µ°°×ÀàÐͺͰе㡣
µ°°×оƬӦÓð¸Àý£º Clin Transl Med| LncRNAÖ±½Ó½áºÏµ°°×µÄɸѡÓëÉîÈë»úÖÆÍÚ¾òµÄ·¶Àý
µã»÷´Ë´¦²é¿´ÎÄÏ×½â¶Á
£¨ËÄ£©Ð¡·Ö×Ó&µ¥¿¹Ò©Îï°Ðµãɸѡ
»¯Ñ§Ð¡·Ö×Ӻ͵¥¿Ë¡¿¹ÌåÊÇÄ¿Ç°Ö÷ÒªµÄ°ÐÏòÒ©ÎïÀ´Ô´£¬È»¶ø¾µäµÄÒ©ÎïÑз¢ÌåϵÍùÍùÐèÒª15-20ÄêµÄʱ¼ä²ÅÄÜ¿ª·¢³öÊÊÓÃÓÚÁÙ´²µÄ°ÐÏòÒ©ÎÇÒÑз¢Ê§°ÜÂʷdz£¸ß¡£
HuProt™20K µ°°×ÖÊ×éоƬ×÷Ϊ¼ò±ã¡¢¿ìËÙºÍ׼ȷµÄÒ©Îï°ÐµãɸѡʵÑé¼¼Êõ£¬¸Ãµ°°×оƬ¿ÉÒÔ¿ìËٵض¨ÐÔºÍÏà¶Ô¶¨Á¿µØ·ÖÎö¾¹ýÓ«¹â¡¢ÉúÎïËرê¼ÇµÄС·Ö×Ó»òµ¥¿Ë¡¿¹ÌåÒ©ÎïÓë~2ÍòÖÖÈËÀàÈ«³¤µ°°×ÖʵĽáºÏÇé¿ö£¬ÅжϺòÑ¡·Ö×ӵĽáºÏ°ÐµãºÍÌØÒìÐÔ£¬ÎªÒ©ÎïÑз¢ÌåϵµÄ¸Ä½øÌṩǿ´óµÄ¼¼Êõ±£ÕÏ¡£
µ°°×оƬӦÓð¸Àý£º µ°°×оƬ¼¼ÊõÓ¦ÓÃÓÚÀ×¹«ÌÙºìËØаеãÑ°ÕÒ£¨Circ. Res., 2020, 126: 1007-1023.£©
µã»÷´Ë´¦²é¿´ÎÄÏ×½â¶Á
| ¿Í»§ÎÄÏ×
[1].Ran L, Zhang S, Wang G et al. Mitochondrial pyruvate carrier-mediated metabolism is dispensable for the classical activation of macrophages. Nat Metab. 2023 May;5(5):804-820.£¨ÉϺ£¶«·½Ò½Ôº MPC£©IF=20.8
[2].Zhao T, Zeng J, Xu Y et al. Chitinase-3 like-protein-1 promotes glioma progression via the NF-κB signaling pathway and tumor microenvironment reprogramming. Theranostics. 2022, Oct 3;12(16):6989-7008.£¨¹ãÖÝÒ½¿Æ´óѧ¸½ÊôÖ×ÁöÒ½Ôº rhCHI3L1£©IF=12.4
[3]. Zhu Yiran, Zhou Bingluo, Hu Xinyang, et al. LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability. Clin Transl Med, 2022, 12: e703.£¨Õã½´óѧҽѧԺ¸½ÊôÉÛÒÝ·òÒ½Ôº LncRNA LINC00942£©IF=11.492
[4]. Wang Guoqing, Li Xingran, Li Na, et al. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biol, 2022, 52: 102297.£¨ÖØÇìÒ½¿Æ´óѧ¸½ÊôµÚÒ»Ò½Ôº ÒùÑòÞ½ÜÕ£©IF=11.4
[5]. Zhou Wen-Jie, Yang Hui-Li, Mei Jie, et al. Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2 macrophage differentiation. Sci Adv, 2022, 8: eabj2488.£¨¸´µ©´óѧ¸½Êô¸¾²ú¿ÆÒ½Ôº 1,6-¶þÁ×Ëá¹ûÌÇ£©IF=14.136
[6]. Gu Yan, Chen Yanrong, Wei Lai, et al. ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation. Nat Commun, 2021, 12: 6711.£¨Â½¾ü¾üÒ½´óѧÎ÷ÄÏÒ½Ôº ÈËABHD5µ°°×£©IF=14.919
[7]. Xu Y, et al. E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e284-e298.£¨Öйúҽѧ¿ÆѧԺҽҩÉúÎï¼¼ÊõÑо¿Ëù E17241£¨Ò©Î£©IF=8.311
[8]. Yu J J, et al. TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target. Nat Commun. 2020 Jul 21;11(1):3660.£¨Öйúҽѧ¿ÆѧԺҩÎïÑо¿Ëù ÈËTRIB3µ°°×£©IF=14.919
[9]. Chen X, et al. Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. Theranostics. 2020 Aug 15;10(22):10290-10308.£¨ÎÂÖÝÒ½¿Æ´óѧҩѧԺ»¯Ñ§ÉúÎïѧÑо¿ÖÐÐÄ À×¹«ÌÙºìËØ£©IF=11.556
[10]. Xu QG, et al. A novel HBx genotype serves as a preoperative predictor and fails to activate the JAK1/STATs pathway in hepatocellular carcinoma. J Hepatol. 2019 May;70(5):904-917.£¨¶«·½¸Îµ¨Íâ¿ÆÒ½Ôº HBV-X²¡¶¾µ°°×£©IF=25.083
[11]. Ou J, et al. ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. Nat Commun. 2019 Mar 6;10(1):1078.£¨Â½¾ü¾üÒ½´óѧÎ÷ÄÏÒ½Ôº ÈËABHD5µ°°×£©IF=14.919
[12]. Kang CL, et al. LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription. Theranostics, 2019 Jun 9;9(15):4421-4436.£¨¸´µ©´óѧ»ù´¡Ò½Ñ§ÔºÉúÎﻯѧÓë·Ö×ÓÉúÎïѧϵ lncRNA AY£©IF=11.556
[13]. Zhao TL, et al. DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell. Theranostics. 2019 Aug 14;9(21):6175-6190.£¨³¤Õ÷Ò½ÔºÃÚÄòÍâ¿Æ ÈËQPCTµ°°×£©IF=11.556
[14]. Shen SM, et al. Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. 2018 Jun 19;9(1):2392.£¨ÉϺ£½»Í¨´óѧҽѧԺ ÈËPTENµ°°×£©IF=14.919
[15]. Wang YY, et al. HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk. J Clin Invest. 2018 Dec 3;128(12):5235-5250.£¨¸´µ©ÉϺ£°©Ö¢ÖÐÐÄ°©Ö¢Ñо¿Ëù ÈËϸ°ûÒò×Óµ°°×CXCL14£©IF=14.808
[16]. Zhang H, et al. Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15084-9.£¨ÉϺ£Èð½ðÒ½Ôº É飩IF=11.205